PeptideTDB

Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials

García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, Simental-Mendía LE, et al.. Int Orthop. 2019; 43(3):531–538.

PubMed 30368550 · doi:10.1007/s00264-018-4211-5

Meta-analysisJoints & tendonsCollagen peptidesOral

Pools the results of several trials. Only as reliable as the trials it includes.

Who or what was studied
Randomised placebo-controlled trials of oral collagen in osteoarthritis (number of trials not given in the abstract)
Design
Meta-analysis, random-effects model

What it found

Collagen lowered the total WOMAC osteoarthritis score (weighted mean difference −8.00; 95% CI −13.04 to −2.95) and the pain visual analogue scale (−16.57; 95% CI −26.24 to −6.89) compared with placebo. Within WOMAC, the stiffness subscore improved.

What it doesn't show

The WOMAC pain and physical-function subscores did not differ significantly from placebo, so the overall result is mixed. The abstract does not say how many trials were pooled or which collagen products were used.

Funding and conflicts of interest

No funding or conflict-of-interest statement appears in the PubMed record. Check the full text.

Summary written from the study's abstract and checked against PubMed on November 9, 2026. How we check studies. Educational information, not medical advice.

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