Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice
Oddoux S, Violette P, Cornet J, Akkoyun-Farinez J, Besnier M, Noël A, et al.. Nutrients. 2022; 14(12):2425.
PubMed 35745154 · PMC9228954 · doi:10.3390/nu14122425
No comparison group, so it cannot separate the treatment from placebo or natural recovery.
- Who or what was studied
- Patients diagnosed with adjustment disorder with anxiety (Hamilton Anxiety score of 20 or more) seen by general practitioners; number not given in the abstract
- Design
- Observational, multicentre, single-arm study with no comparison group
- Dose
- A supplement combining fish-protein-hydrolysate peptides (Gabolysat), magnesium and vitamin B6
- Duration
- 28 days
What it found
Average Hamilton anxiety scores fell by 12.1 points (from 25.6 to 13.6, p < 0.001), 41.9% of patients had a 50% reduction in score, and clinicians rated 75.3% as improved.
What it doesn't show
No control group, so it cannot separate the supplement from placebo, natural recovery or other care. The product also contained magnesium and vitamin B6, so any change cannot be attributed to the peptides.
Funding and conflicts of interest
Three of the authors work for Laboratoire Dielen.
Summary written from the study's abstract and checked against PubMed on November 9, 2026. How we check studies. Educational information, not medical advice.
Related studies
- Dietary fish hydrolysate improves episodic memory in healthy elderly with lower level of memory performance: a double-blind, randomized, placebo-controlled clinical study (Chataigner et al., 2026)
- Efficacy of a fish hydrolysate supplement on sleep quality: A randomized, double-blind, placebo-controlled, crossover clinical trial (Eckert et al., 2024)