The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials
Asserin J, Lati E, Shioya T, Prawitt J. J Cosmet Dermatol. 2015; 14(4):291–301.
PubMed 26362110 · doi:10.1111/jocd.12174
Compares people who got the treatment with people who did not.
- Who or what was studied
- Two placebo-controlled trials plus a lab experiment on human skin samples
- Design
- Two randomised, placebo-controlled trials and an ex vivo skin-explant model
What it found
Daily oral collagen peptides raised skin hydration after 8 weeks. Collagen density in the dermis rose and fragmentation of the collagen network fell from week 4, and both effects were still present at 12 weeks. In skin samples in the lab, collagen peptides increased production of collagen and glycosaminoglycans.
What it doesn't show
The abstract gives no participant numbers, doses or funder, so the trials cannot be weighed on size. The skin-sample result suggests a mechanism; it is not a clinical outcome.
Funding and conflicts of interest
No funding or conflict-of-interest statement appears in the PubMed record. Check the full text.
Summary written from the study's abstract and checked against PubMed on November 9, 2026. How we check studies. Educational information, not medical advice.
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