Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis
de Miranda RB, Weimer P, Rossi RC. Int J Dermatol. 2021; 60(12):1449–1461.
PubMed 33742704 · doi:10.1111/ijd.15518
Pools the results of several trials. Only as reliable as the trials it includes.
- Who or what was studied
- 19 randomised, double-blind, controlled trials; 1,125 participants aged 20–70 (95% women)
- Design
- Systematic review and meta-analysis of randomised trials
What it found
Pooled results favoured hydrolysed collagen over placebo for skin hydration, elasticity and wrinkles. The authors conclude that taking it for about 90 days is effective at reducing signs of skin aging.
What it doesn't show
Nearly all participants were women. The abstract reports no effect sizes and says nothing about the quality of the included trials, so it does not show how large or how reliable the benefit is.
Funding and conflicts of interest
No funding or conflict-of-interest statement appears in the PubMed record. Check the full text.
Summary written from the study's abstract and checked against PubMed on November 9, 2026. How we check studies. Educational information, not medical advice.
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