Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis
Pu SY, Huang YL, Pu CM, Kang YN, Hoang KD, Chen KH, et al.. Nutrients. 2023; 15(9):2080.
PubMed 37432180 · PMC10180699 · doi:10.3390/nu15092080
Pools the results of several trials. Only as reliable as the trials it includes.
- Who or what was studied
- 26 randomised controlled trials; 1,721 participants
- Design
- Systematic review and meta-analysis of randomised trials
What it found
Hydrolysed collagen improved skin hydration and elasticity compared with placebo (both p < 0.00001). The size of the hydration effect varied with the source of the collagen and how long it was taken; elasticity did not differ by source.
What it doesn't show
The authors found several biases in the trials they included and say larger confirmatory trials are needed, so the direction is consistent but the size of the effect is uncertain.
Funding and conflicts of interest
Wan Fang Hospital is listed as a funder. The authors declare no conflict of interest and say the funders had no role in the design, analysis or publication.
Summary written from the study's abstract and checked against PubMed on November 9, 2026. How we check studies. Educational information, not medical advice.
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- GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration (Pickart et al., 2015)